New research indicates that individuals who discontinue blockbuster slimming jabs like Wegovy and Mounjaro may regain reduced body mass far faster than those who halt traditional lifestyle programs.
Research printed in a major medical journal demonstrates that while overweight individuals can lose a large proportion of their body weight while using the jabs, the weight returns at an estimated rate of 0.8 kg per month after stopping.
"People purchasing such drugs need to be aware of the risk of rapid weight regain when the medication ends," stated researcher Dr. Susan Jebb.
Such speed of regain suggests a return to original weight in about a year and a half.
Analyzing Treatments
The analysis, which reviewed 37 of studies involving over 9,000 of patients, contrasted the effects of these new drugs with conventional dieting.
Scientists point out that people who shed pounds through diet and exercise typically have a slower creep back—around 0.1 kg a month—once they finish.
Understanding the Fast Rebound
Experts propose the mode of action of the jabs accounts for the heightened regain.
The injections mimic a natural hormone called glucagon-like peptide-1, which moderates hunger.
"Sustained high doses of the hormone levels far above than the body's typical production might result in the body to generate a reduced amount of its own natural hormone, and could reduce responsiveness to its effects," said Dr. Adam Collins, a nutrition researcher.
"Stopping of this hormone supplement leads to appetite is no longer kept in check, making overeating a significant risk."
An Ongoing Condition?
The NHS recommend the injections for people with weight-linked medical conditions, accompanied by prescribed diet and exercise modifications.
Professionals argue that, given the significant potential of relapse, the therapy should be considered ongoing.
This opinion is reinforced by drug manufacturers, who state that the results "highlight the chronic nature of excess weight," comparing it to managing diseases like high blood pressure.
Patient Experiences
Users who have stopped the medication report a sudden resurgence of hunger.
"I experienced a trigger flipping and you're instantly ravenous," recalled a patient.
This challenge is compounded if users have not adopted lasting lifestyle or habit modifications during therapy.
Significant Use
Figures show that a significant number of people in the UK have tried weight-loss jabs in the last 12 months, with interest being substantial.
- Use is higher among females compared to males.
- The middle-aged age group shows the greatest level of interest.
- Many obtain the drugs through private prescriptions rather than public health services.
Finally, experts emphasize that while the jabs are potent tools for weight loss, they are not a standalone solution and maintained weight loss hinges on combined lifestyle changes.
